Exclzyme-2AF Double-Strength Joint Formula
An Aching Affliction
Inflammation is a vital process in the human body. It helps protect
vulnerable organs and tissues from greater damage following an injury.
It also initiates the chemical processes that heal the body and promote
recovery. However, millions of people suffer from persistent levels of
unhealthy inflammation, which can cause pain and swelling that never
seem to end. Healthcare practitioners are increasingly convinced that
unhealthy inflammation is at the center of many cardiovascular,
immunity, brain and joint conditions.
When considering joint
disorders such as rheumatoid arthritis and osteoarthritis, inflammation
is a serious concern as it is known to worsen their symptoms. Chronic
inflammation is localized in the joint capsule, creating pain upon
movement and reducing the functionality of the appendage. If left
untreated, these conditions can lead to bone degeneration and/or a
build-up of fibrin - a protein molecule accumulate around damaged tissue
-within the affected joint. Treating the inflammation is a crucial part
of joint health maintenance.
Given the relative commonality of
joint-related pain and inflammation, many turn to readily available
over-the-counter non-steroidal anti-inflammatory drugs (NSAIDs) such as
aspirin, acetaminophen or ibuprofen for relief. While these drugs are
effective for initial signs of inflammation like pain and swelling, they
do not encourage the repair of damaged tissue. In fact, with prolonged
use, they can even cause additional damage to the gastro-intestinal
Exclzyme® 2AF for Joint and Inflammation Support
Exclzyme® 2AF is a clinically-proven blend of proteolytic
enzymes, herbs, vitamins and minerals for powerful joint support. In
addition to papain and bromelain, Exclzyme® 2AF features
serrapeptase, a systemic enzyme known for its capacity to restore normal
inflammatory marker levels and promote healthy circulation.* Exclzyme
2AF is an all-natural way to support the body’s healthy response to
inflammation and promote recovery within the body.*
Exclzyme 2AF features Peptizyme SP®
brand serrapeptase. A systemic enzyme, serrapeptase passes through the
small intestine into the bloodstream purifying the body of dead cells
in and around damaged tissues. Used widely for its fibrinolytic
properties, research and clinical studies consistently show serrapeptase
can help break down non-living tissue that is often the result of the
inflammatory process. By breaking down this old cellular debris,
serrapeptase improves blood circulation in the affected area, allowing
vital nutrients and building blocks to nourish new cells.*
addition to Serrapeptase, which can block pain-inducing chemicals
involved in the inflammatory response, Exclzyme 2AF contains boswellia
and turmeric. These herbs are traditionally known for their
anti-inflammatory properties and are widely used as an alternative
therapy. For antioxidant support, Exclzyme 2AF contains vitamin C, amla,
rutin and grape seed extract.
Exclzyme® 2AF Dosage
For best results, begin enzyme regiment at a low dosage of 1 capsule
three times a day. After three days, increase your Exclzyme 2AF dosage
to 2 capsules three times a day. After the first week, doses should be
adjusted to a therapeutic level of 3 or more capsules three times a day
(amount is dependent upon desired benefit).
NOTE: It is important
to continue therapeutic doses until results are realized. This should
then be reduced to a maintenance dose of 1-3 capsules three times a day.
your Exclzyme 2AF with additional serrapeptase can increase proteolytic
activity, as well as increase positive effects on inflammation and
provide faster recovery and healing from injury.*Peptizyme-SP contains 80,000 units of professional-strength serrapeptase per capsule.
Exclzyme vs. Exclzyme 2AF
Many people have asked the question, “What is the difference between full-strength Exclzyme and Exclzyme 2AF?” This is usually accompanied by, “Which one should I take?”
When looking at the ingredients of the products side-by-side, the
initial differences become very clear – Exclzyme 2AF has a more
comprehensive blend of enzymes and assisting ingredients than Exclzyme.
However, the two Exclzyme products were intentionally designed to be
very similar. Both products are intended to support a healthy
When first choosing an enzyme supplement, we at AST Enzymes recommend starting with the original full-strength Exclzyme.
has an excellent consumer acceptability profile – used safely for over
10 years, Exclzyme has demonstrated time and time again just how
beneficial the anti-inflammatory properties of these proteolytic enzymes
are. For many, relief from symptoms has been reported in as little as
one bottle. However for some, the activity in full-strength Exclzyme may
not be enough.
For those who struggle with severe inflammation and are looking for something more, AST Enzymes has the solution: Exclzyme 2AF.
2AF is considered “extra-strength”, due to the additional nutrients and
herbs included in the formula. Those who have tried full-strength
Exclzyme for up to 3 months with varying success have found that making
the switch to Exclzyme 2AF made the difference in their pain and
Exclzyme 2AF for Severe Joint Pain and Inflammation
significant difference between the two Exclzyme products is their
intended activity. Exclzyme 2AF has been formulated with particular
interest in addressing the pain and inflammation associated with the
joints. By including various supporting nutrients such as vitamin C, B
vitamins, calcium and folate, Exclzyme 2AF has an increased capacity for
targeting cartilage repair, which is a key aspect of managing joint
The use of additional herbs in Exclzyme 2AF is another
way this product has specific benefits to joint health. Boswellia, also
known as Indian frankincense, has been used traditionally as an
Ayurvedic herb for its anti-inflammatory properties.* Likewise, the
active ingredient in turmeric has been shown to relieve pain associated
with arthritis and help improve joint function.* Grape seed extract’s
antioxidant capacity has also been attributed to reduced joint pain.*
Exclzyme 2AF Research
than 15 different studies have been performed on Exclzyme, including a
clinical trial to observe serrapeptase’s effect on pain and
inflammation. The results may affirm German doctor and atherosclerosis
specialist Dr. Hans Napier claim: “Serrapeptase is the miracle enzyme.”
Studies show Exclzyme:
- Reduces C-reactive protein levels
- Is a natural alternative to NSAIDs
- Improves sports injury recovery
- Improves range of motion for people with back problems
Exclzyme vs. NSAIDS
Complete resolution in less time
Exclzyme 2AF includes
serrapeptase. Studies and research demonstrate serrapeptase is effective
as an all-natural, non-toxic alternative to NSAIDs (Non-Steroid
Anti-Inflammatory Drugs). Many people turn to NSAIDs such as aspirin,
ibuprofen, and naproxen for temporary relief, but these drugs are known
to cause serious damage to the intestinal lining (ulcers), kidneys, and
liver. In fact, gastrointestinal complications from prolonged NSAID use
is the primary cause for emergency room visits in the United States.
Exclzyme 2AF and Joint Pain
In addition to Serrapeptase, which can block pain-inducing chemicals
involved in the inflammatory response, Exclzyme 2AF contains boswellia
and turmeric. These herbs are traditionally and widely known for their
anti-inflammatory properties. For antioxidant support, Exclzyme 2AF
contains vitamin C, amla, rutin and grape seed extract.
1. Patki M. Study of anti-inflammatory and analgesic efficacy of Exclzyme ™ EN. J Orthopedics. 1999; 33(4):157-170.
Enzyme Activity in Exclzyme®2AF Proprietary Blend
|Enzymes||How it Works|
needed by the body for tissue growth and repair, adrenal gland
function, and for healthy gums, joints, ligaments, artery walls and
|Vitamin B6||Also called
pyroxidine; helps regulate immune function, glucose metabolism, nerve
communication and homocysteine levels in the blood*|
for overall bone support; also important for normal heart, nerve and
muscle function, as well as proper blood clotting*|
water-soluble vitamin essential for healthy nerve function, red blood
cell formation and protein metabolism; works with enzymes in the
creation of new DNA*|
nutrient in the production of myelin, a chemical that insulates nerve
cells in the transmission of neuro-electrical impulses; also has a
positive effect on high homocysteine levels associated with
(Peptizyme SP® Brand)
|Enzyme used by silkworms to digest and emerge from their
silken cocoons; studied extensively for more than 50 years and found to
be an excellent fibrinolytic (fibrin digesting) enzyme anti-inflammatory
(break-down) proteins like casein, steak, gelatin, soy, fish and other
plant and animal proteins to smaller chains of polypeptides (small
proteins) and amino acids for easier uptake throughout the body*|
collective name for the proteolytic (protein-digesting) enzymes found
in the pineapple plant (Ananas comosus); known for its digestive
properties; a good substitute for animal-based enzymes pepsin and
trypsin for digestive support because of its activity across a wide pH
|Papain||Obtained from the latex of the fruit of the Papaya tree, papain has been used for centuries as an effective digestive aid*|
down carbohydrates, or more specifically, starches, into smaller
dextrins and sugars; produced naturally by humans, microorganisms and
|Amino Peptidase||Protein-digesting enzyme with higher selectivity than other proteases*|
|Lipase||Catalyzes the break-down of fats into essential fatty acids needed for healthy tissues and cells*|
known as Indian gooseberry (Emblica officinalis); a natural,
efficacious antioxidant, and one of the richest sources of absorbable
|Rutin||Bioflavonoid; strengthens and tones arteries and veins, and provides antioxidant support against free-radicals and inflammation*|
|Grapeseed Extract||Scientifically proven to be abundant in bioflavonoids, which are known for their tremendous antioxidant properties*|
plant of India and often used in Indian herbal medicine; used
extensively in Ayurvedic medicine as a useful remedy for many
rhizomatous herbaceous perennial plant of the ginger family; used for
centuries in Ayurvedic medicine. Curcumin, its active ingredient,
provides antioxidant support, inhibits blood stickiness and supports
overall blood vessel integrity|
What is systemic enzyme therapy?
enzyme therapy refers to the therapeutic use of natural enzymes to
produce desired healing effects. Systemic enzymes are absorbed from the
small intestine where they enter the bloodstream and execute their
effects on the entire body as a system. Their crucial role in normal
inflammatory response assists and supports the body in accelerating
healing. Exclzyme 2AF is specially formulated for joint health, making
it perfect for athletes and sports-related injuries.
What is a systemic proteolytic enzyme?
enzymes break down proteins into their building-blocks, which are
called amino acids. Systemic proteolytic enzymes are responsible for
breaking down accumulated protein and waste substances found in the
circulatory system and connective tissue. Waste materials produced from
inflammation and other biochemical processes can build up, contributing
to an abnormal inflammation response, which is accompanied by increased
pain. The waste product of specific concern is known as fibrin. Regular
systemic proteolytic enzyme use can improve circulation and aid in
flushing out these waste products.
What is fibrin?
is a protein-based substance that is needed to help clot one’s blood,
playing a substantial role in immune response and healing. When the body
responds to injury or chronic inflammation, fibrin is recruited to the
damaged area to form scar tissue. Although the body is equipped with
plasmin, a naturally occurring enzyme responsible for breaking down
excess fibrin, some people are at a disadvantage – as aging occurs,
plasmin levels progressively decrease. This actually increases the risk
for excessive, undesirable scar tissue formation in the body.
Are systemic enzymes anti-inflammatory drugs?
systemic enzymes produce anti-inflammatory effects, they are not
considered a drug. Since enzymes are naturally occurring within the
body, systemic enzyme therapy is considered supplementation. One
difference between systemic enzymes and NSAIDs (Non-steroidal
anti-inflammatory drugs) involves the duration of action. While NSAIDs
produce short-term pain relief, systemic enzymes can produce long-term
alleviation with appropriate use. The largest difference between NSAIDS
and systemic enzymes is the mechanism of action and possible side
effects. NSAIDs block the production of prostaglandins, which are
responsible for inflammation and swelling. However, prostaglandins
protect the lining of the stomach, and prolonged use of NSAIDs can
reduce this protection and increase the risk of developing ulcers.
Conversely, regular use of systemic enzymes has no negative side effects
and can actually provide protective effects against excess
Why is it important to take Exclzyme 2AF on an empty stomach?
most absorption occurs in the small intestine, the systemic enzymes
must bypass the stomach to gain access there. If the enzymes are taken
with food, they will likely begin working to break down your food within
the stomach, rather than passing through to the small intestine. Taking
systemic enzymes like Exclzyme 2AFwith food will compromise their
absorption, as well as their effectiveness.
Does Exclzyme 2AF have an enteric coating?
the serrapeptase in Exclzyme 2AF is enterically coated. While similar
systemic enzymes may have the same active ingredients, most do not
utilize enteric coating. The purpose of enteric coating is to protect
the enzyme from the acidic environment of the stomach. High activity
level is preserved until the enzymes reach the small intestine, where
absorption into the bloodstream takes place. While the enteric coating
can withstand the acidic environment of the stomach, the alkaline
environment of the small intestine will disintegrate the enteric
coating, allowing the enzyme to become active within the bloodstream.
Do you use phthalates in your enteric coating?
AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric
coating. Compared to other commonly used enteric coating agents such as
Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose
Phthalate (HPMCP), MAAC is the most gastro-resistant, which means that
it can most effectively withstand the acidity of the stomach, allowing
its contents to be released in the small intestine and absorbed
Don’t let the name scare
you.MAAC is a food-grade compound that is listed as Generally Recognized
as Safe (GRAS) by the Food and Drug Administration (FDA). In addition,
the Environmental Protection Agency (EPA) conducted various studies and
found sufficient information to reasonably conclude that the current
use pattern of MAAC will not adversely affect public health or the
Unlike CAP, MAAC is not
under regulation by California Proposition 65, which states that the
ingredient is found by the state of California to cause cancer, birth
defects, or other reproductive harm. In fact, the European Food Safety
Authority – an organization that conducted studies which led to the ban
of 6 types of phthalates in personal care products in Europe in 2004 –
has deemed MAAC safe for use as coating agent in food supplements. This
conclusion on the safety of MAAC is derived from the findings of
How long should I take Exclzyme 2AF before feeling results?
people experience varying ailments and severity of disease, the length
of time to include systemic enzymes in your regimen may vary as well. As
an overall guideline, it is typically recommended that new systemic
enzyme users start off slow. A starter dose is generally one capsule,
three times daily. After three to four days of proven tolerance, the
dose can be increased to a therapeutic dose of 3 capsules, 3 times per
day. At this point, results may be monitored, and dosage should be
adjusted accordingly. Some consumers find their therapeutic dose between
9-12 capsules per day, while others only need 3-6. There are several
factors that may affect results and required dosage, including:
- Severity of symptoms
- Time of administration (Better absorbed on an empty stomach)
- Adherence to regimen
- Nutritional state
What if I miss a dose?
consistent use of systemic enzymes will provide the best results,
however missed doses of systemic enzymes do not have serious
repercussions. Although symptoms alleviated by systemic enzyme therapy
may resurface, getting back on track by remembering to take your next
dose will suffice. There is also the option of incorporating another
dose during the day. There is no need to “double up,” on one dose - and
remember, systemic enzymes are best absorbed on an empty stomach.
Are there any side effects involved with Exclzyme 2AF?
use of Exclzyme 2AF has not been shown to exhibit detrimental effects,
neither long term nor short term. Just as dosage requirements vary, side
effects may vary as well. Although gastrointestinal disturbances have
been reported by a small percentage of new users, tolerance is
maintained once the dosage is adjusted. Minor allergic reactions, like
reddening of the skin, are also rare occurrences, and can be seen with
extremely high doses. There are no known interactions with prescription
or over the counter drugs while using systemic enzyme therapy. However,
it is recommended that you consult with your physician about starting
systemic enzymes, especially if you are currently on blood-thinning
medications or if you are pregnant or nursing.
Can I take Exclzyme 2AFwith other systemic enzymes?
enzymes may be taken together, yielding desirable results, as long as
they are taken on an empty stomach. In fact, it is often recommended
that systemic enzymes be combined. Products like Exclzyme 2AF and
Peptizyme-SP often have synergistic effects when taken together. This
means that the separate products work together to produce advantageous
results. By combining and enhancing the activity of the enzymes, their
effects on the healing process are more attainable.
Can I take Exclzyme 2AF with digestive enzymes?
Although digestive and systemic enzymes arenot
contraindicated in terms of ingredients, they cannot be taken at the
same time. The purpose of digestive enzymes is to aid in digestion of
specific foods, so taking them with food is an obvious recommendation.
Because systemic enzymes require an empty stomach for maximum
absorption, they must be taken separately from digestive enzymes. There
are no adverse interactions between systemic and digestive enzymes, but
they serve different purposes and thus should be taken as directed for
Free of pesticides, chemicals, preservatives, animal
derivatives, dairy, lactose, yeast, fish or shellfish, peanuts, tree
nuts, artificial sweeteners and colors.
All individual enzymes and probiotics are kosher-certified, and suitable for vegetarians and vegans.
Bioactive Protein Peptide System (BPPS®) is a proprietary
manufacturing process featuring complementary bioactive peptides,
ensuring greater enzyme stability, absorption and bio-availability.
The products and the claims made about specific products on this site have not been evaluated by the United States Food and Drug Administration .
This product is not intended to diagnose, treat, cure, or prevent any disease or medical condition. Please consult a physician or medical practitioner before taking this or any dietary supplement. Women who are pregnant, nursing, or are planning on becoming pregnant should not take any supplements without consulting their physician first.
All material on this website is for informational purposes only. Nothing
contained on this website is intended to be used as a medical diagnosis
or treatment. It should not be used in place of the advice of your
physician or qualified healthcare provider.
is a registered trademark of World Nutrition Inc., which is not
affiliated with, nor sponsors or endorses this product or any other
product from Specialty Enzymes & Biotechnologies or AST Enzymes.
Detailed Product Information
- Healthy response to inflammation
- Healthy joint function
- Sports injury recovery
- Supports fibrin metabolism
- Healthy C-reactive protein levels